The longstanding issue of the benefit of ursodeoxycholic acid in primary sclerosing cholangitis: a long-term population-based study - Summary - MDSpire
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Evaluating the Efficacy of Ursodeoxycholic Acid in Primary Sclerosing Cholangitis: Findings from a Long-Term Population Study

  • By

  • Bregje Mol

  • Kim van Munster

  • Rinse Weersma

  • Akin Inderson

  • Kirsten Boonstra

  • Joost Drenth

  • Suzanne van Meer

  • Elsemieke de Vries

  • Marcel Spanier

  • Anton Vrij

  • Tessa Verlaan

  • Femke van Duijn

  • Willemijn Ponsioen

  • Marcel Dijkgraaf

  • Cyriel Ponsioen

  • June 15, 2026

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Objective:

To assess the effectiveness of ursodeoxycholic acid (UDCA) on transplant-free survival in patients with primary sclerosing cholangitis (PSC) through a long-term population-based observational study, addressing significant treatment gaps.

Key Findings:
  • UDCA has been used in PSC treatment despite lack of evidence for improving transplant-free survival. The study found that UDCA did not significantly improve transplant-free survival rates in the cohort.
Interpretation:

The findings will contribute to understanding the role of UDCA in the management of PSC, particularly regarding its impact on survival without liver transplantation, potentially guiding future treatment protocols.

Limitations:
  • The study may be subject to biases inherent in population-based registries, such as selection bias and reporting bias. Specific examples include the reliance on self-reported data for UDCA usage.
Conclusion:

The study seeks to clarify the effectiveness of UDCA in PSC patients, addressing a significant gap in current treatment understanding and potentially influencing clinical guidelines.

Sources:

Original Source(s)

The longstanding issue of the benefit of ursodeoxycholic acid in primary sclerosing cholangitis: a long-term population-based study

  • by Bregje Mol, Kim van Munster, Rinse Weersma, Akin Inderson, Kirsten Boonstra, Joost Drenth, Suzanne van Meer, Elsemieke de Vries, Marcel Spanier, Anton Vrij, Tessa Verlaan, Femke van Duijn, Willemijn Ponsioen, Marcel Dijkgraaf, Cyriel Ponsioen

  • June 15, 2026

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