Fractures in Adults After Weight Loss from Bariatric Surgery and Weight Management Programs for Obesity: Systematic Review and Meta-analysis - Summary - MDSpire
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Fractures in Adults After Weight Loss from Bariatric Surgery and Weight Management Programs for Obesity: Systematic Review and Meta-analysis
To examine whether weight loss from bariatric surgery or lifestyle weight management programs (WMPs) increases the risk of fractures compared to adults with obesity who did not undergo these interventions.
Key Findings:
Limited randomized controlled trials (RCTs) reporting fracture data post-bariatric surgery.
High risk of bias in several studies due to high dropout rates and industry funding, which may affect the reliability of findings.
Observational studies indicated a higher incidence of fractures in patients post-bariatric surgery compared to controls.
Interpretation:
Weight loss interventions, particularly bariatric surgery, may be associated with an increased risk of fractures, potentially due to malnutrition and reduced bone mineral density (BMD), which can compromise bone health.
Limitations:
Limited data from RCTs and observational studies.
High dropout rates and potential biases in study designs.
Short maximum follow-up period of 2 years, which may not capture long-term fracture risk.
Conclusion:
Further research is needed to fully understand the long-term fracture risk associated with weight loss interventions in obese adults.
A long-term cohort study found that obesity was not associated with worse patient-reported outcomes or higher reoperation rates following total ankle replacement in optimized surgical candidates.
