Updated Asian consensus guidelines for the diagnosis and management of gastrointestinal stromal tumor (2025) - Summary - MDSpire

Updated Asian consensus guidelines for the diagnosis and management of gastrointestinal stromal tumor (2025)

  • By

  • Hidekazu Hirano

  • Yoichi Naito

  • Tsuyoshi Takahashi

  • Seiichi Hirota

  • Kyoung-Mee Kim

  • Min-Hee Ryu

  • Jian Wang

  • Hui Cao

  • Jian Li

  • Chien-Feng Li

  • Chueh-Chuan Yen

  • Han-Kwang Yang

  • Hwoon-Yong Jung

  • Chun-Nan Yeh

  • Hsiu-Po Wang

  • Li-Tzong Chen

  • Lin Shen

  • Yoon-Koo Kang

  • Toshirou Nishida

  • July 15, 2026

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Objective:

To provide updated Asian guidelines for the management of gastrointestinal stromal tumors (GIST).

Approach:
  • Guideline Development: The guidelines were developed through a narrative overview of key considerations in the diagnosis and treatment of GIST, with input from a panel of 19 experts across four domains.
Key Findings:
  • GISTs primarily occur in the stomach (60%) and small intestine (30%).
  • GISTs can also occur in the rectum (5%), esophagus (1%), colon (< 1%), and appendix (< 1%).
  • Immunohistochemistry (IHC) is crucial for confirming GIST diagnosis, with c-KIT and DOG-1 being key markers.
  • GISTs can be histologically classified into spindle cell type (70%), epithelioid cell type (20%), and mixed cell type (10%).
Interpretation:

Limitations:
  • The guidelines were developed through a narrative review rather than a systematic review.
  • Formal grading of the level of evidence was not performed.
Conclusion:

The revised guidelines aim to optimize the management of GIST for Asian patients based on the latest evidence and expert consensus.

Original Source(s)

Updated Asian consensus guidelines for the diagnosis and management of gastrointestinal stromal tumor (2025)

  • by Hidekazu Hirano, Yoichi Naito, Tsuyoshi Takahashi, Seiichi Hirota, Kyoung-Mee Kim, Min-Hee Ryu, Jian Wang, Hui Cao, Jian Li, Chien-Feng Li, Chueh-Chuan Yen, Han-Kwang Yang, Hwoon-Yong Jung, Chun-Nan Yeh, Hsiu-Po Wang, Li-Tzong Chen, Lin Shen, Yoon-Koo Kang, Toshirou Nishida

  • July 15, 2026

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