To examine the determinants of the immunometabolic landscape in brain tumors and the distinct features of heterogeneous myeloid cell populations.
Approach:
Review: This systematic review discusses the metabolic reprogramming of myeloid cells in the tumor microenvironment (TME) of brain tumors, particularly glioblastoma (GBM).
Key Findings:
Myeloid cells constitute up to 30% of tumor mass in GBM, indicating their significant role in disease progression.
The GBM TME induces metabolic rewiring in myeloid cells, leading to immunosuppression.
Distinct myeloid populations exhibit unique metabolic adaptations, including altered lipid metabolism and the utilization of fructose via the fructose transporter GLUT5.
Interpretation:
The review discusses the interactions between tumor cells and myeloid populations, focusing on the role of the TME in shaping immune cell metabolism.
Limitations:
Limited knowledge on the molecular determinants of myeloid cell responses in the TME.
The review primarily focuses on metabolic aspects and does not extensively explore other immunological factors.
Conclusion:
The findings highlight the importance of understanding metabolic states in myeloid cells within the TME.
