To explore the topological alterations in metabolic connectivity associated with focal epilepsy subtypes (RTLE, LTLE, ETLE) and their prognostic implications.
Approach:
Key Findings:
RTLE, LTLE, and ETLE groups showed significant alterations in metabolic network connectivity compared to healthy controls (p < 0.01, FDR-corrected).
Key disparity nodes identified in RTLE included the right Rolandic area and bilateral cerebellum; in LTLE, notable variations were found in the left middle temporal gyrus and right fusiform gyrus; ETLE abnormalities were linked to the unilateral postcentral gyrus and other regions.
In the ETLE group, edge connectivity of certain cerebral regions positively correlated with prognosis classifications.
Interpretation:
Distinct topological characteristics of metabolic networks in focal epilepsy were observed.
Limitations:
The study is retrospective and may have inherent biases.
Limited exploration of the whole brain metabolic connectivity in individual patients.
Conclusion:
The findings provide a foundation for understanding the metabolic connectivity variations in focal epilepsy.
Guidance addresses office readiness, recommended equipment and medications, and team communication processes for infrequent but high-acuity emergencies.
