Early Childhood Neurodevelopmental Outcomes After Early Infant Invasive Group B Streptococcal Infection in Uganda - Summary - MDSpire

Early Childhood Neurodevelopmental Outcomes After Early Infant Invasive Group B Streptococcal Infection in Uganda

  • By

  • Samantha Sadoo

  • Carol Nanyunja

  • Mary Kyohere

  • Hannah G Davies

  • Valerie Tusubira

  • Cleophas Komugisha

  • Joseph Peacock

  • Margaret Sewegaba

  • Philippa Musoke

  • Musa Sekikubo

  • Kirsty Le Doare

  • Cally J Tann

  • PROGRESS Study Author Group

  • Abdelmajid Djennad

  • Agnes Nyamaizi

  • Agnes Ssali

  • Alexander Amone

  • Amusa Wamawobe

  • Annettee Nakimuli

  • Caitlin Farley

  • Carol Nanyunja

  • Christine Najuka

  • Cleophas Komugisha

  • Dan R Shelley

  • Edward A R Portal

  • Ellie Duckworth

  • Emilie Karafillakis

  • Geraldine O’Hara

  • Godfrey Matovu

  • Hannah G Davies

  • Janet Seeley

  • Joseph Peacock

  • Juliet Nsimire Sendagala

  • Katie Cowie

  • Kirsty Le Doare

  • Konstantinos Karampatsas

  • Lauren Hookham

  • Madeleine Cochet

  • Margaret Sewegaba

  • Mary Kyohere

  • Maxensia Owor

  • Melanie Etti

  • Merryn Voysey

  • Moses Musooko

  • Musa Sekikubo

  • Owen B Spiller

  • Patience Atuhaire

  • Paul T Heath

  • Philippa Musoke

  • Phiona Nalubega

  • Pooja Ravji

  • Richard Katungye

  • Ritah Namugumya

  • Rosalin Parks

  • Rose Azuba

  • Sam Kipyeko

  • Simon Beach

  • Stephen Bentley

  • Tim Old

  • Tobius Mutabazi

  • Valerie Tusubira

  • Vicki Chalker

  • March 10, 2025

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Objective:

To assess neurodevelopmental and growth outcomes at 24 months in infants who survived invasive GBS sepsis compared to a matched cohort of infants without GBS sepsis.

Key Findings:
  • Survivors of GBS sepsis had lower cognitive and language scores compared to the non-GBS cohort (p-values to be included).
  • 31% of GBS sepsis survivors exhibited moderate to severe neurodevelopmental impairment versus 8.5% in the comparison group.
  • 25% of GBS survivors were undernourished compared to 10% in the comparison group, with severe undernutrition noted in those with cerebral palsy.
Interpretation:

Survivors of GBS sepsis in Uganda are at a significantly higher risk for neurodevelopmental impairments and growth issues compared to their peers, indicating a need for long-term follow-up and support in healthcare policy.

Limitations:
  • Small sample size of GBS sepsis survivors (16) may limit generalizability and introduce selection bias.
  • Data primarily from a single urban setting may not reflect rural experiences.
Conclusion:

The study highlights the need for ongoing monitoring and support for GBS sepsis survivors to address potential neurodevelopmental and growth challenges.

Original Source(s)

Early Childhood Neurodevelopmental Outcomes After Early Infant Invasive Group B Streptococcal Infection in Uganda

  • by Samantha Sadoo, Carol Nanyunja, Mary Kyohere, Hannah G Davies, Valerie Tusubira, Cleophas Komugisha, Joseph Peacock, Margaret Sewegaba, Philippa Musoke, Musa Sekikubo, Kirsty Le Doare, Cally J Tann, PROGRESS Study Author Group, Abdelmajid Djennad, Agnes Nyamaizi, Agnes Ssali, Alexander Amone, Amusa Wamawobe, Annettee Nakimuli, Caitlin Farley, Carol Nanyunja, Christine Najuka, Cleophas Komugisha, Dan R Shelley, Edward A R Portal, Ellie Duckworth, Emilie Karafillakis, Geraldine O’Hara, Godfrey Matovu, Hannah G Davies, Janet Seeley, Joseph Peacock, Juliet Nsimire Sendagala, Katie Cowie, Kirsty Le Doare, Konstantinos Karampatsas, Lauren Hookham, Madeleine Cochet, Margaret Sewegaba, Mary Kyohere, Maxensia Owor, Melanie Etti, Merryn Voysey, Moses Musooko, Musa Sekikubo, Owen B Spiller, Patience Atuhaire, Paul T Heath, Philippa Musoke, Phiona Nalubega, Pooja Ravji, Richard Katungye, Ritah Namugumya, Rosalin Parks, Rose Azuba, Sam Kipyeko, Simon Beach, Stephen Bentley, Tim Old, Tobius Mutabazi, Valerie Tusubira, Vicki Chalker

  • March 10, 2025

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