Three-dimensional image guidance for diagnosis and treatment of adrenal disease: a systematic review - Summary - MDSpire

Three-dimensional image guidance for diagnosis and treatment of adrenal disease: a systematic review

  • By

  • Sofia Di Lorenzo

  • Farahdiba Zarin

  • Matteo Pavone

  • Didier Mutter

  • Marco Raffaelli

  • Michel Vix

  • Barbara Seeliger

  • October 9, 2025

  • 0 min

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Objective:

To analyze the clinical utility of 3D imaging in improving diagnostic accuracy, guiding treatment strategies, and enhancing surgical outcomes in adrenal disease, specifically through a systematic review.

Key Findings:
  • Adrenal abnormalities are prevalent, especially in the elderly, with a significant proportion being benign.
  • Surgical overtreatment occurs in 30-55% of cases due to benign histopathology, highlighting the need for improved diagnostic tools.
  • 3D imaging tools enhance diagnostic accuracy and surgical planning, reducing unnecessary surgeries, as evidenced by recent studies.
Interpretation:

3D imaging, including volumetric reconstructions and AI-assisted techniques, shows promise in improving the management of adrenal diseases by providing better diagnostic clarity and surgical guidance, potentially leading to more tailored treatment approaches.

Limitations:
  • Lack of comprehensive literature synthesis on the role of 3D imaging in adrenal disease, which may hinder the generalizability of findings.
  • Potential biases in study selection and reporting outcomes, which could affect the reliability of the conclusions drawn.
Conclusion:

3D imaging technologies have the potential to significantly improve the diagnosis and treatment of adrenal diseases, minimizing unnecessary surgeries and preserving healthy tissue, thus enhancing patient outcomes.

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