Prophylactic Strategies for Venous Thromboembolism in Total Shoulder Arthroplasty: Analysis of Matched Cohorts - Summary - MDSpire

Prophylactic Strategies for Venous Thromboembolism in Total Shoulder Arthroplasty: Analysis of Matched Cohorts

  • By

  • Akhil Katakam

  • Tej Joshi

  • Thomas Soussou

  • Francis Sirch

  • Tuckerman Jones

  • Teren Yedikian

  • John Erickson

  • April 29, 2026

  • 0 min

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Objective:

To assess the incidence of venous thromboembolism (VTE), bleeding events, and related outcomes in patients undergoing total shoulder arthroplasty (TSA) with and without standardized VTE prophylaxis, including specific surgical and medical complications.

Key Findings:
  • The study included 11,719 patients with DVT prophylaxis and 10,505 without, with 9,859 in each cohort after propensity matching.
  • No significant difference in VTE incidence was found between the two groups, suggesting similar risk profiles.
  • Bleeding events and other complications were comparable across both cohorts, indicating the need for individualized patient assessment.
Interpretation:

The findings suggest that standardized VTE prophylaxis may not significantly reduce the incidence of VTE or related complications in TSA patients, highlighting the need for further research to identify optimal prophylaxis strategies tailored to individual risk factors.

Limitations:
  • The study did not account for mechanical VTE prophylaxis, which may have influenced outcomes and the observed low VTE incidence.
  • Data was limited to the TriNetX database, potentially affecting generalizability to broader populations and clinical settings.
Conclusion:

Standardized VTE prophylaxis may not be necessary for TSA patients, but further studies are needed to establish effective prevention strategies as the demand for TSA increases, ensuring patient safety and optimal outcomes.

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