Oncologic impact of delaying radical prostatectomy in men with intermediate- and high-risk prostate cancer: a systematic review - Summary - MDSpire

Oncologic impact of delaying radical prostatectomy in men with intermediate- and high-risk prostate cancer: a systematic review

  • By

  • Ekaterina Laukhtina

  • Reza Sari Motlagh

  • Keiichiro Mori

  • Fahad Quhal

  • Victor M. Schuettfort

  • Hadi Mostafaei

  • Satoshi Katayama

  • Nico C. Grossmann

  • Guillaume Ploussard

  • Pierre I. Karakiewicz

  • Alberto Briganti

  • Mohammad Abufaraj

  • Dmitry Enikeev

  • Benjamin Pradere

  • Shahrokh F. Shariat

  • May 28, 2021

  • 0 min

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Objective:

To summarize the available evidence on the survival and pathologic outcomes after deferred radical prostatectomy (RP) in men with intermediate- and high-risk prostate cancer (PCa), particularly in the context of treatment delays due to COVID-19.

Key Findings:
  • Nineteen studies were included in the review, showing significant heterogeneity in definitions of RP delay, which may affect the comparability of results.
  • Most studies defined a delay of 3 months between diagnosis and RP.
  • Some studies included low-risk patients without separate analyses for risk groups.
Interpretation:

Delays in radical prostatectomy for intermediate- and high-risk PCa may have variable oncological impacts, but high-level evidence is still lacking, highlighting the need for further investigation.

Limitations:
  • Heterogeneity in study definitions and methodologies may limit the generalizability of the findings.
  • Inclusion of studies with mixed risk groups without separate analysis could obscure the true impact of treatment delays.
Conclusion:

Further research is needed to clarify the oncological impact of delaying radical prostatectomy in intermediate- and high-risk prostate cancer patients, particularly focusing on specific delay durations and patient demographics.

Original Source(s)

Oncologic impact of delaying radical prostatectomy in men with intermediate- and high-risk prostate cancer: a systematic review

  • by Ekaterina Laukhtina, Reza Sari Motlagh, Keiichiro Mori, Fahad Quhal, Victor M. Schuettfort, Hadi Mostafaei, Satoshi Katayama, Nico C. Grossmann, Guillaume Ploussard, Pierre I. Karakiewicz, Alberto Briganti, Mohammad Abufaraj, Dmitry Enikeev, Benjamin Pradere, Shahrokh F. Shariat

  • May 28, 2021

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