Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial - Summary - MDSpire

Internet-based indicated prevention of anxiety and depression disorder onset three-arm randomized clinical trial

  • By

  • Anna-Carlotta Zarski

  • Kiona K. Weisel

  • Thomas Berger

  • Tobias Krieger

  • Michael P. Schaub

  • Matthias Berking

  • Dennis Görlich

  • Corinna Jacobi

  • Rosa Baños

  • Cristina Botella

  • Rocio Herrero

  • David D. Ebert

  • October 1, 2025

  • 0 min

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Objective:

To evaluate the efficacy of internet-based indicated prevention for anxiety and depressive disorders in reducing the onset of these conditions among adults with subthreshold symptoms.

Key Findings:
  • AD/DD onset was 19.4% in IG-IMI, 14.8% in AG-IMI, and 30.9% in WLC, with p < 0.001 indicating statistical significance.
  • Cumulative incidence was 23.1% (IG-IMI), 20.7% (AG-IMI), and 36.0% (WLC; p < 0.001).
  • Hazard ratios were 0.59 for IG-IMI and 0.47 for AG-IMI compared to WLC, indicating a significant reduction in risk.
Interpretation:

Both individually guided and automated internet-based interventions significantly reduced the incidence of anxiety and depressive disorders compared to the waitlist control, suggesting their potential as effective preventive measures.

Limitations:
  • The study relied on self-reported measures and diagnostic interviews, which may introduce bias.
  • Participant dropout rates varied across groups, potentially affecting the results and limiting generalizability.
Conclusion:

Internet-based interventions, whether individually or automatically guided, are effective in preventing the onset of anxiety and depressive disorders, highlighting the need for scalable mental health prevention strategies.

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