Objective:

To investigate whether pre-treatment multidisciplinary team (MDT) care is associated with improved outcomes, specifically local recurrence and distant metastasis, in FNCLCC grade 3 soft tissue sarcoma (STS).

Approach:

Key Findings:

• MDT care was associated with lower 3-year local recurrence (6.8% vs 21.2%; unadjusted OR = 0.272, 95% CI not provided, P = 0.002).
• Results remained consistent after PSM (paired OR = 0.259, 95% CI not provided, P = 0.021) and IPTW (OR = 0.296, 95% CI not provided, P = 0.008).
• No significant difference in 3-year distant metastasis between groups (weighted OR = 0.846, 95% CI 0.418–1.714, P = 0.643).

Interpretation:

Pre-treatment MDT care was associated with improved 3-year local control in FNCLCC grade 3 STS, suggesting potential benefits for clinical practice, but did not significantly reduce 3-year distant metastasis.

Limitations:

• Retrospective design may introduce selection bias, potentially affecting the generalizability of the findings.
• Adherence to MDT recommendations was not systematically captured, which may influence outcomes.

Conclusion:

MDT care improves local control in FNCLCC grade 3 STS but does not significantly affect distant metastasis outcomes.

Source

Based on findings from:

Multidisciplinary team care and outcomes in FNCLCC grade 3 soft tissue sarcoma: a propensity score–matched and weighted cohort study

Zhangfu Li, Xinyu Li, Baicheng Yang, Xiaoyang Li, Luqiang Wang, Ting Liu, Xinxin Zhang, Zhenguo Zhao, Libin Xu, Helin Feng, Zhenfeng Li, Shengji Yu. Frontiers In Oncology, 2026.

https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1827237/full

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