Objective:

To provide a comprehensive review on the application of phytomedicines in preventing and treating antipsychotic-induced extrapyramidal symptoms (EPS) by summarizing their therapeutic effects and underlying neurobiological mechanisms.

Approach:

Key Findings:

• Clinical research indicates beneficial effects of herbal medicines on EPS in patients with schizophrenia.
• Most studies reviewed are animal studies demonstrating that herbal medicines can prevent or improve EPS-like behaviors.
• Neurobiological mechanisms include regulation of monoaminergic neurotransmission, alleviation of oxidative stress, maintenance of mitochondrial function, suppression of neuroinflammation, and modulation of the KEAP1/Nrf2 pathway.

Interpretation:

The results support the combination of herbal medicines with antipsychotic drugs for the prevention and treatment of EPS in patients with schizophrenia.

Limitations:

• The majority of existing research consists of animal studies rather than extensive clinical trials.
• A few negative reports exist regarding the efficacy of herbal medicines.

Conclusion:

The review highlights the potential of phytomedicines in addressing EPS induced by antipsychotic drugs.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.