Case Report: Paradoxical worsening of hypoxemia with PEEP during one-lung ventilation: a case of pressure-dependent intracardiac shunting - Summary - MDSpire

Case Report: Paradoxical worsening of hypoxemia with PEEP during one-lung ventilation: a case of pressure-dependent intracardiac shunting

  • By

  • Xinrui Yin

  • Shijia Du

  • June 15, 2026

  • 0 min

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Objective:

To describe a case where escalation of PEEP during one-lung ventilation led to paradoxical hypoxemia due to a pressure-dependent right-to-left intracardiac shunt.

Approach:
    Key Findings:
    • Remove any implications about clinical practice.
    Interpretation:

    Revise to focus solely on the case details without unsupported conclusions.

    Limitations:
    • Intraoperative echocardiography was nondiagnostic due to limited acoustic windows.
    • Routine preoperative screening for PFO was not performed in this asymptomatic patient.
    Conclusion:

    Revise to reflect only the findings of the case without recommendations.

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