Objective:

To investigate the role of extracellular Cyclophilin A (eCypA) in neuroinflammation and blood-brain barrier (BBB) injury in acute ischemic stroke (AIS).

Approach:

Key Findings:

• eCypA levels were significantly elevated in the serum of AIS patients and in tMCAO rat models compared to healthy controls.
• C46 peptide administration resulted in changes in neurological function, cerebral infarct volume, and BBB permeability in tMCAO rats.
• C46 administration preserved tight junction protein levels and inhibited microglial activation and proinflammatory mediator expression.

Interpretation:

Limitations:

• The study involved a limited number of AIS patients and animal models.
• Further research is needed to fully elucidate the mechanisms by which eCypA contributes to neuroinflammation and BBB damage.

Conclusion:

Attribution Notice

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