Objective:

To investigate the association between preoperative systemic immune-inflammation index (SII) and early objective optical quality following phacoemulsification cataract surgery.

Approach:

Key Findings:

• Higher preoperative log2-SII was significantly associated with lower internal MTF average height at postoperative 1 week and 1 month.
• No significant association was found at 1 day postoperative.
• Exploratory analyses indicated that the low-SII group had better internal Strehl ratio, lower total higher-order aberrations, and higher dysfunctional lens index at 1 month.

Interpretation:

Higher preoperative SII was associated with less favorable early postoperative internal MTF average height, suggesting systemic inflammatory status may influence early optical recovery.

Limitations:

• Findings from exploratory analyses require confirmation in future studies.
• Postoperative visual acuity did not differ between groups, indicating that SII may affect optical quality without impacting visual acuity.

Conclusion:

Despite comparable visual acuity, systemic inflammatory status may contribute to interindividual variability in early optical recovery after cataract surgery.

Source

Based on findings from:

Association Between Systemic Immune-Inflammation Index and Postoperative Optical Quality in the Early Recovery Phase After Cataract Surgery: A Retrospective Study

Zang, Huaixiao , Shi, Dong . Frontiers In Medicine, 2026.

https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2026.1837927/full

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