The pathogenesis and surgical treatment progress of gastroesophageal reflux disease
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By
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Longmiao Gu
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Fan Wu
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Jie Cheng
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Xiaojun Shen
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May 25, 2026
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Objective:
To summarize the current understanding of the pathogenesis of GERD and recent advances in surgical treatment as presented in the source.
Key Findings:
- GERD prevalence is rising globally, with significant regional variations as noted in the source.
- Pathogenesis involves dysfunction of the lower esophageal sphincter and other anatomical components as described in the source.
- Surgical intervention is necessary for patients with severe symptoms or complications as stated in the source.
- Minimally invasive techniques such as robot-assisted surgery and magnetic sphincter augmentation are advancing as highlighted in the source.
Interpretation:
Limitations:
- Further exploration is needed regarding the concept of 'asymptomatic elective repair' for hiatal hernia patients, as mentioned in the source.
Conclusion:
Surgical treatment options are evolving, focusing on minimal invasiveness and functional preservation as indicated in the source.