The pathogenesis and surgical treatment progress of gastroesophageal reflux disease - Summary - MDSpire

The pathogenesis and surgical treatment progress of gastroesophageal reflux disease

  • By

  • Longmiao Gu

  • Fan Wu

  • Jie Cheng

  • Xiaojun Shen

  • May 25, 2026

  • 0 min

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Objective:

To summarize the current understanding of the pathogenesis of GERD and recent advances in surgical treatment as presented in the source.

Key Findings:
  • GERD prevalence is rising globally, with significant regional variations as noted in the source.
  • Pathogenesis involves dysfunction of the lower esophageal sphincter and other anatomical components as described in the source.
  • Surgical intervention is necessary for patients with severe symptoms or complications as stated in the source.
  • Minimally invasive techniques such as robot-assisted surgery and magnetic sphincter augmentation are advancing as highlighted in the source.
Interpretation:

Limitations:
  • Further exploration is needed regarding the concept of 'asymptomatic elective repair' for hiatal hernia patients, as mentioned in the source.
Conclusion:

Surgical treatment options are evolving, focusing on minimal invasiveness and functional preservation as indicated in the source.

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