Comparative effects of structured exercise protocols on depression and anxiety symptoms: a network meta-analysis - Summary - MDSpire

Comparative effects of structured exercise protocols on depression and anxiety symptoms: a network meta-analysis

  • By

  • Zhiyuan Zhang

  • Fengyun Li

  • Can Han

  • Wenkun Song

  • Sifan Pu

  • June 8, 2026

  • 0 min

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Objective:

To systematically compare the intervention effects of eight common structured exercise modalities on depressive and anxiety symptoms in adults using a network meta-analysis approach, providing evidence-based insights for developing precision exercise prescriptions in mental health.

Key Findings:
  • 22 studies involving 23 randomized controlled trials with 1,830 participants were included.
  • Exercise intervention groups showed significant improvements in depressive symptoms (SMD = -0.67) and anxiety symptoms (SMD = -0.77) compared to control groups.
  • Yoga ranked first in both depression (SUCRA = 68.8%) and anxiety (SUCRA = 72.2%) improvement.
  • No statistically significant differences in effect sizes were found among yoga, moderate-intensity continuous training (MICT), and high-intensity interval training (HIIT), indicating no clear superiority among these interventions.
  • Subgroup analyses indicated larger effect sizes in the elderly group (≥60 years).
Interpretation:

Different exercise modalities exhibit beneficial effects on both depression and anxiety symptoms, with yoga, MICT, and HIIT showing significant potential, though no significant differences among them were found.

Limitations:
  • Only one study included Pilates, limiting its independent effect validation.
  • Potential publication bias was suggested by Egger’s test, which may affect the robustness of the findings.
Conclusion:

Yoga, MICT, and HIIT are viable prioritized exercise modalities in clinical practice for alleviating depression and anxiety symptoms, with individualized regimens based on patient characteristics being essential.

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