Combined prognostic value of lipoprotein(a) and an integrated inflammatory-lipid index in patients with acute coronary syndrome and type 2 diabetes mellitus - Summary - MDSpire
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Prognostic Significance of Lipoprotein(a) and a Novel Inflammatory-Lipid Index in Individuals with Acute Coronary Syndrome and Type 2 Diabetes Mellitus
To evaluate the combined prognostic value of Lipoprotein(a) [Lp(a)] and a novel Inflammatory-Lipid Index in patients with acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM).
Key Findings:
Both Lp(a) and the Inflammatory-Lipid Index were independent predictors of major adverse cardiovascular events (MACE).
Patients in the dual-high group (high Lp(a) and high Inflammatory-Lipid Index) had a MACE incidence of 57.7% and an 8-fold higher risk compared to the dual-low reference.
The addition of both biomarkers improved predictive performance and reclassification in cardiovascular risk models.
Interpretation:
Limitations:
The study was retrospective and conducted at a single center, which may limit generalizability.
The requirement for written informed consent was waived, which may raise ethical considerations.
