Combined prognostic value of lipoprotein(a) and an integrated inflammatory-lipid index in patients with acute coronary syndrome and type 2 diabetes mellitus - Summary - MDSpire

Combined prognostic value of lipoprotein(a) and an integrated inflammatory-lipid index in patients with acute coronary syndrome and type 2 diabetes mellitus

  • By

  • Tingting Li

  • Hongliang Cong

  • Lin Wang

  • Wei Ruo

  • Wenyu Li

  • June 2, 2026

  • 0 min

Share

Objective:

To evaluate the combined prognostic value of Lipoprotein(a) [Lp(a)] and a novel Inflammatory-Lipid Index in patients with acute coronary syndrome (ACS) and type 2 diabetes mellitus (T2DM).

Key Findings:
  • Both Lp(a) and the Inflammatory-Lipid Index were independent predictors of major adverse cardiovascular events (MACE).
  • Patients in the dual-high group (high Lp(a) and high Inflammatory-Lipid Index) had a MACE incidence of 57.7% and an 8-fold higher risk compared to the dual-low reference.
  • The addition of both biomarkers improved predictive performance and reclassification in cardiovascular risk models.
Interpretation:

Limitations:
  • The study was retrospective and conducted at a single center, which may limit generalizability.
  • The requirement for written informed consent was waived, which may raise ethical considerations.
Conclusion:

Original Source(s)

Combined prognostic value of lipoprotein(a) and an integrated inflammatory-lipid index in patients with acute coronary syndrome and type 2 diabetes mellitus

  • by Tingting Li, Hongliang Cong, Lin Wang, Wei Ruo, Wenyu Li

  • June 2, 2026

Related Content

Tenecteplase Fails to Boost EVT Outcomes

Phase 3 stroke trial leaves open the possibility of clinically meaningful benefit or harm in selected late-window patients.

Top 10 States for Physician-Owned Hospitals

These 10 states make it more practical for physicians to participate in hospital ownership by aligning statutory structure, corporate practice of medicine rules, and population trends.

Side Effects: Variety Is Overrated

The organ you forgot, the cells that age unevenly, the AI that admits ignorance, and the diet advice that sounds wrong but isn't: medicine's next moves are hiding in plain sight.