Urosepsis 30-day mortality, morbidity, and their risk factors: SERPENS study, a prospective, observational multi-center study - Summary - MDSpire

Urosepsis 30-day mortality, morbidity, and their risk factors: SERPENS study, a prospective, observational multi-center study

  • By

  • Zafer Tandogdu

  • Bela Koves

  • Slobodan Ristovski

  • Mustafa Bahadir Can Balci

  • Kristin Rennesund

  • Stavros Gravas

  • DjordJe Nale

  • José Medina-Polo

  • Mária Kopilec Garabášová

  • Elisabetta Costantini

  • Jorge Cano-Valasco

  • Maja Sofronievska Glavinova

  • Franck Bruyere

  • Tamara Perepanova

  • Ekaterina Kulchavenya

  • Mete Cek

  • Florian Wagenlehner

  • Truls Erik Bjerklund Johansen

  • May 10, 2024

  • 0 min

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Objective:

To provide a descriptive report of mortality and morbidity in the first 30 days after the diagnosis of urosepsis and explore risk factors for unfavorable outcomes, emphasizing the significance of these factors in improving patient care.

Key Findings:
  • 354 patients met sepsis-2 criteria with identified pathogens and completed 30-day follow-up, highlighting the need for targeted interventions.
  • Median age was 65.1 years, with 45% females, indicating a demographic that may require tailored care.
  • 3.4% presented with septic shock; 45.5% had severe sepsis, underscoring the severity of cases.
  • Gram-negative bacteria were the predominant pathogens, accounting for 82% of urine cultures, which has implications for antibiotic stewardship.
Interpretation:

The study highlights the importance of identifying risk factors associated with urosepsis to improve patient outcomes, despite the relatively low mortality rates, and suggests that these findings can inform clinical practice.

Limitations:
  • The study's reliance on SIRS criteria may lead to overdiagnosis of sepsis, potentially skewing results.
  • Potential biases in patient selection and data collection across multiple centers could affect the generalizability of the findings.
Conclusion:

Identifying patient factors at diagnosis can enhance understanding and management of urosepsis, ultimately improving care and outcomes, particularly in light of the evolving landscape of urosepsis treatment.

Original Source(s)

Urosepsis 30-day mortality, morbidity, and their risk factors: SERPENS study, a prospective, observational multi-center study

  • by Zafer Tandogdu, Bela Koves, Slobodan Ristovski, Mustafa Bahadir Can Balci, Kristin Rennesund, Stavros Gravas, DjordJe Nale, José Medina-Polo, Mária Kopilec Garabášová, Elisabetta Costantini, Jorge Cano-Valasco, Maja Sofronievska Glavinova, Franck Bruyere, Tamara Perepanova, Ekaterina Kulchavenya, Mete Cek, Florian Wagenlehner, Truls Erik Bjerklund Johansen

  • May 10, 2024

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