Bridging aging and colorectal cancer: Synergistic roles of inflammaging and immunosenescence
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By
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Zaongo, Silvere D
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Yang, Qiyu
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Han, Mei
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Xi, Tianlan
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Luo, Zilang
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Wang, Xin
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Yang, Jiadan
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Ouyang, Jing
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May 12, 2026
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Objective:
To explore the immunological mechanisms linking aging to colorectal cancer (CRC) risk, focusing on inflammaging and immunosenescence.
Key Findings:
- Aging is a key risk factor for colorectal cancer, with incidence and mortality increasing in older adults.
- Inflammaging leads to a tumor-promoting microenvironment through oxidative stress and cytokine activation.
- Immunosenescence reduces immune surveillance, impairing the clearance of premalignant cells and responses to tumor progression.
Interpretation:
Inflammaging and immunosenescence create an immunological framework that predisposes the aging colon to malignant transformation.
Limitations:
Conclusion:
Insights from this review may inform future biomarker discovery, prevention, and therapeutic strategies for colorectal cancer in aging populations.
