Hormonal Influence on Corneal Changes in Keratoconus: A Comprehensive Analysis of Tomographic and Biomechanical Differences by Gender, Age, and Menstrual Cycle - Summary - MDSpire
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Hormonal Influence on Corneal Changes in Keratoconus: A Comprehensive Analysis of Tomographic and Biomechanical Differences by Gender, Age, and Menstrual Cycle
To explore the associations between sex hormones and corneal pathophysiology in keratoconus patients by evaluating serum hormone profiles alongside morphological and biomechanical corneal parameters.
Approach:
Key Findings:
Keratoconus patients had significantly lower testosterone levels compared to controls.
Male keratoconus patients exhibited lower estradiol levels than controls.
No significant age-related differences in hormone levels were observed among male participants.
Interpretation:
The findings suggest that sex hormones may play a role in the pathophysiology of keratoconus, with lower testosterone and estradiol levels observed in affected individuals.
Limitations:
Cross-sectional design limits causal inferences.
Sample size may not be representative of the broader population.
Exclusion of patients with active ocular diseases may affect generalizability.
Conclusion:
This study highlights the potential influence of sex hormones on corneal changes in keratoconus, warranting further investigation into their role in disease progression.
This article will discuss the HOAs associated with keratoconus, how contact lenses can be used to correct aberrations, the efficacy of this correction, and the concept of neuroadaptation; it will conclude with cases of successful HOA reduction with scleral lenses.
