From the Journals

Anti-CD146 Linked to Silica in Systemic Sclerosis

Comparative analysis across exposed workers, cancer controls, and healthy donors supports specificity.

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This study explores the association of anti-CD146 autoantibodies with systemic sclerosis, highlighting their correlation with occupational exposure, particularly to crystalline silica. It examined 93 systemic sclerosis patients, revealing a 15% positivity rate for anti-CD146 antibodies, compared to 5% in healthy controls. Notably, this antibody showcases 57% sensitivity and 88% specificity for indicating occupational exposure. The findings suggest that AACD146 may serve as a significant biomarker in diagnosing and managing systemic sclerosis related to occupational factors, despite limitations in study design.

Original Source(s)

Anti-CD146 Linked to Silica in Systemic Sclerosis

  • by Kathryn Wighton

  • March 5, 2026

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