HPV Vaccine Uptake Varied Widely Across US States - Summary - MDSpire

HPV Vaccine Uptake Varied Widely Across US States

Analysis of more than 16,000 US adolescents found substantial variation in HPV vaccination uptake both across and within census regions

  • By

  • Andrea Surnit

  • May 12, 2026

  • 4 min

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Objective:

To analyze HPV vaccine uptake among US adolescents and identify state-level variations in vaccination rates.

Key Findings:
  • Substantial differences in HPV vaccine uptake across US states, with some states showing significantly lower uptake compared to Alabama, including specific percentages.
  • Rhode Island had the highest adjusted odds of HPV vaccine uptake, while Mississippi had the lowest.
  • Significant regional heterogeneity was observed, with some states in traditionally high-performing regions underperforming.
Interpretation:

The study highlights the importance of state-level analyses in understanding HPV vaccine uptake, as regional analyses may obscure significant differences that affect vaccination strategies.

Limitations:
  • Some state-level estimates had wide confidence intervals due to smaller sample sizes.
  • Cross-sectional design limits causal conclusions.
  • Did not evaluate potential drivers of state-level variation such as vaccine policy, access to care, provider recommendation practices, or parental attitudes.
Conclusion:

State-level differences in HPV vaccine uptake are critical for targeted vaccination efforts, indicating that regional analyses alone may not provide a complete picture of vaccination needs.

Original Source(s)

HPV Vaccine Uptake Varied Widely Across US States

  • by Andrea Surnit

  • May 12, 2026

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