Influence of Helicobacter pylori Infection on Gut and Tumor Microbiomes and Its Relationship with Immunotherapy Outcomes in Gastrointestinal Malignancies - Summary - MDSpire

Influence of Helicobacter pylori Infection on Gut and Tumor Microbiomes and Its Relationship with Immunotherapy Outcomes in Gastrointestinal Malignancies

  • By

  • Keren Jia

  • Yang Chen

  • Die Dai

  • Yi Xie

  • Haoxin Peng

  • Yanshuo Cao

  • Hua Zou

  • Chuangzhao Qiu

  • Yan Tan

  • Xiaotian Zhang

  • Zhihao Lu

  • Xiaochen Yin

  • Zhi Peng

  • Jian Li

  • Lin Shen

  • January 12, 2026

  • 0 min

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Objective:

To evaluate the role of H. pylori-driven microbiome changes, specifically in gut and intratumoral microbiomes, in gastrointestinal cancer patients and its impact on immunotherapy outcomes.

Key Findings:
  • H. pylori-positive GC patients had a median irPFS of 6.97 months compared to 5.03 months for H. pylori-negative patients (p < 0.001), indicating a statistically significant difference.
Interpretation:

H. pylori infection appears to enhance the efficacy of immunotherapy in GC patients by remodeling the gut microbiome, which may influence immune responses through various mechanisms.

Limitations:
  • 123
Conclusion:

H. pylori infection may be a favorable factor for immunotherapy outcomes in gastrointestinal malignancies, warranting further investigation into its mechanisms and potential therapeutic implications.

Original Source(s)

Influence of Helicobacter pylori Infection on Gut and Tumor Microbiomes and Its Relationship with Immunotherapy Outcomes in Gastrointestinal Malignancies

  • by Keren Jia, Yang Chen, Die Dai, Yi Xie, Haoxin Peng, Yanshuo Cao, Hua Zou, Chuangzhao Qiu, Yan Tan, Xiaotian Zhang, Zhihao Lu, Xiaochen Yin, Zhi Peng, Jian Li, Lin Shen

  • January 12, 2026

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