Parent-mediated early intervention in infants and toddlers at elevated likelihood for autism: a systematic review of randomized controlled trials - Summary - MDSpire

Parent-mediated early intervention in infants and toddlers at elevated likelihood for autism: a systematic review of randomized controlled trials

  • By

  • E. Conti

  • F. Ieri

  • S. Calderoni

  • F. Apicella

  • N. Chericoni

  • V. Costanzo

  • Viviana Marchi

  • A. Guzzetta

  • C. Colombi

  • April 13, 2026

  • 0 min

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Objective:

To summarize evidence on outcomes from Randomized Control Trials (RCTs) of parent-mediated early interventions in infants with early signs of Autism Spectrum Disorder (ASD) or elevated likelihood for ASD, emphasizing the critical need for early intervention.

Key Findings:
  • Parent-mediated interventions can be delivered effectively within community services.
  • Early intervention before 24 months is associated with greater developmental gains.
  • No clear impact of early intervention on neurodevelopmental trajectories was found, although a positive trend was noted, which was not statistically significant.
Interpretation:

The findings suggest that while parent-mediated interventions show promise, their effectiveness on child developmental outcomes remains inconclusive, warranting further investigation to clarify these results.

Limitations:
  • Limited number of studies included in the review.
  • Variability in intervention methodologies and outcome measures across studies may introduce biases.
Conclusion:

Parent-mediated early interventions may provide a feasible approach to support infants at risk for ASD, but more rigorous studies are needed to establish their effectiveness.

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