To examine brain networks related to hyperactivity and impulsivity in children with ADHD and develop a resting-state functional connectivity marker to predict symptom severity.
Approach:
Key Findings:
The CPM model successfully predicted hyperactivity–impulsivity symptoms (SNAP-IV ratings: r = 0.48, p = 0.001).
The model generalized well within the dataset, predicting scores on the Conners Parent Rating Scale (r = 0.49, p = 0.0009).
Stronger connectivity between the frontoparietal control network (FPN) and the dorsal attention network (DAN) was related to symptom severity.
Weaker connectivity between the FPN and the ventral attention network (VAN) and somatomotor network (SMN) was also associated with symptom severity.
Interpretation:
Remove unsupported conclusions about the role of FPN-related networks.
Limitations:
The study sample size was relatively small (n=44).
Further validation is needed to confirm the findings as a reliable neuroimaging marker.
Conclusion:
Remove unsupported claims regarding the findings as a candidate for a neuroimaging marker.
Federal prosecutors allege that a Florida physician and research staff fabricated clinical trial records that were submitted into database systems used to evaluate investigational drugs.
