Comparative effectiveness of statins, metformin, and vitamin D, for prevention of preeclampsia: a systematic review and network meta-analysis of randomized trials - Summary - MDSpire
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Efficacy Comparison of Statins, Metformin, and Vitamin D in Preeclampsia Prevention: A Systematic Review and Network Meta-Analysis of Randomized Trials
To assess whether statins, metformin, or vitamin D with or without omega-3 prevent preeclampsia and other adverse outcomes in high-risk pregnant women.
Approach:
Protocol Registration: Conducted following the PRISMA 2020 statement and its network meta-analysis extension, with protocol registered in PROSPERO.
Inclusion Criteria: Included randomized controlled trials involving high-risk pregnant individuals, evaluating metformin, statins, vitamin D, or omega-3.
Search Strategy: Comprehensive search of RCTs published in English from September 11, 2020, to September 11, 2025.
Key Findings:
Statins, metformin, and vitamin D have been investigated for their potential roles in preventing preeclampsia.
Current evidence on the comparative efficacy of these agents is limited, with low-dose aspirin being the only recommended preventive intervention for high-risk women.
Interpretation:
The analysis aims to provide comparative estimates and hypothesis-generating rankings rather than definitive clinical recommendations due to the sparse network structure.
Limitations:
Limited number of randomized trials available for analysis.
Clinical heterogeneity due to varying definitions of high-risk pregnancy and outcomes across studies.
Conclusion:
The study highlights the need for further research to establish the comparative efficacy of statins, metformin, and vitamin D in preventing preeclampsia.
by Menna Alaa El-Khouly, Mazen Mohammed Mahgoub, Mahmoud E. Abd-Elkareem, Noreen M. El-Bayaa, Jana M. Farouk, Mariam M. Fouad, Habiba Mohammed Salah, Ahmed Khaled Saad, Mohammed Al-azab, Rofida Ayman Mohamed, Kholoud Dahshan, Dalia Atef Abouda
