Objective:

To investigate the association between the rs6498486 polymorphism in the ERCC4 gene and breast cancer risk among Bangladeshi women, highlighting its potential significance in cancer genetics.

Key Findings:

• The rs6498486 polymorphism in the ERCC4 gene may be associated with increased breast cancer risk (p-value < 0.05).
• Carriers of the C/C genotype of rs6498486 showed a higher risk of breast cancer.
• The frequency of the C allele varies significantly among different ethnic populations.

Interpretation:

The findings suggest that the ERCC4 rs6498486 polymorphism could serve as a potential biomarker for breast cancer susceptibility in Bangladeshi women, similar to associations observed in other populations, warranting further investigation into its clinical applications.

Limitations:

• The study was limited to a specific ethnic group, which may affect the generalizability of the results and introduce potential biases.
• Sample size may not be sufficient to draw definitive conclusions.

Conclusion:

The ERCC4 rs6498486 polymorphism may play a significant role in breast cancer risk among Bangladeshi women, warranting further research to confirm these findings and explore potential clinical applications, particularly in targeted screening strategies.