To analyze how genetic background and environment shape human biology through a multiomics survey of healthy adults across different ancestry groups and continents.
Key Findings:
Ethnicity showed strong associations with immune, metabolic, pathogen, and microbiome features.
South Asian participants had higher pathogen-reactive antibody signatures.
Individuals of European ancestry exhibited greater gut microbial diversity and elevated levels of lipid and metabolite classes linked to cardiovascular and metabolic risk.
Geography influenced molecular and microbial profiles, with shifts in cholesterol, bile acid, and arachidonic acid pathways observed in participants living outside their ancestral regions.
Biological age varied by geography, with East Asian participants showing lower biological age in East Asia and European ancestry participants showing lower biological age in the US and Canada.
Interpretation:
The study provides an open-access dataset that enhances understanding of how molecular and microbial baselines differ across populations, potentially refining precision medicine.
Limitations:
Conclusion:
The resulting dataset offers a comprehensive resource for studying human molecular diversity and its implications for health.
