Clinicogenomic Features and Outcomes of Adenoid Cystic Carcinoma With Central Nervous System Metastases: A Single-Institution Cohort Study - Summary - MDSpire
To describe the clinical characteristics, CNS disease patterns, molecular features, treatment modalities, and outcomes of patients with ACC and CNS involvement.
Approach:
Study Design: Retrospective cohort study of patients with biopsy-confirmed ACC and CNS involvement treated at the University of Pennsylvania.
Patient Identification: Patients were identified through an institutional cancer registry query and electronic medical record review.
CNS Involvement Classification: CNS involvement was categorized by dominant radiographic pattern, including hematogenous parenchymal metastasis, leptomeningeal disease, and neurotropic or perineural extension.
Treatment Assessment: CNS-directed treatment modalities and systemic therapies were abstracted, and radiographic responses were categorized.
Statistical Analysis: Descriptive statistics summarized baseline characteristics, and survival estimates were calculated using Kaplan–Meier methods.
Key Findings:
Seventeen patients with ACC and CNS involvement were identified.
Median age at initial ACC diagnosis was 54 years.
Most patients had primary tumors in the head and neck region.
Interpretation:
Limitations:
Small sample size limits the generalizability of findings.
Exploratory nature of statistical analyses due to cohort size.
