Development and internal validation of a nomogram for predicting short-term functional improvement after pharmacological treatment in severe symptomatic lumbar disk herniation - Summary - MDSpire

Development and internal validation of a nomogram for predicting short-term functional improvement after pharmacological treatment in severe symptomatic lumbar disk herniation

  • By

  • Hanze Mao

  • Guangqi Lu

  • Shuaiqi Zhou

  • Minghui Zhuang

  • Xin Xiu

  • Jing Li

  • Xinyue Sun

  • Yakun Liu

  • Mingming Ma

  • Jiaming Hu

  • Jie Yu

  • Liguo Zhu

  • June 8, 2026

  • 0 min

Share

Objective:

To develop and internally validate a nomogram to predict 14-day improvement in the Oswestry Disability Index (ODI) in patients with severe lumbar disk herniation (LDH) following pharmacological treatment, highlighting the importance of individualized treatment responses.

Key Findings:
  • The optimal prediction model included six variables: treatment group, sex, alkaline phosphatase (ALP), angular instability, degree of disk herniation (DDH), and hypertrophy of the ligamentum flavum (HLF), with implications for clinical practice.
Interpretation:

The internally validated nomogram may assist in estimating short-term functional improvement after pharmacological treatment in severe LDH.

Limitations:
  • Short follow-up period, limited sample size, and absence of external validation, which may affect the generalizability of the findings.
Conclusion:

The model should be considered preliminary and requires further validation before routine clinical use, with potential applications in pre-treatment risk stratification.

Original Source(s)

Development and internal validation of a nomogram for predicting short-term functional improvement after pharmacological treatment in severe symptomatic lumbar disk herniation

  • by Hanze Mao, Guangqi Lu, Shuaiqi Zhou, Minghui Zhuang, Xin Xiu, Jing Li, Xinyue Sun, Yakun Liu, Mingming Ma, Jiaming Hu, Jie Yu, Liguo Zhu

  • June 8, 2026

Related Content

Retraction: Deficits in the thalamocortical pathway associated with hypersensitivity to pain in patients with frozen shoulder

  • June 1, 2026

Three-dimensional correction of cubitus varus deformity using patient-specific 3D-printed osteotomy guides

The clinical efficacy analysis of ultrasound-assisted minimally invasive treatment for Jakob Type II humeral lateral condyle fractures in children