Early Life Neurodevelopmental Indicators of Attention-Deficit/Hyperactivity Disorder at Age 10: A Prospective Cohort Study - Summary - MDSpire

Neurodevelopmental Markers in Early Childhood as Predictors of ADHD at Age 10: Findings from a Longitudinal Cohort Study

  • By

  • Camilla Grube

  • María Hernández-Lorca

  • Julie Rosenberg

  • Kristina Aagaard

  • Michael Widdowson

  • Tingting Wang

  • Nilo Vahman

  • Hanne Lunn Nissen

  • Jens Richardt Møllegaard Jepsen

  • Klaus Bønnelykke

  • Bjørn H. Ebdrup

  • Bo Chawes

  • Rebecca K. Vinding

  • July 20, 2026

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Objective:

To investigate associations between early neurodevelopmental measures from birth to age three and ADHD outcomes at age 10, including both categorical and dimensional ADHD traits.

Approach:
  • Method: label
  • Method: text
Key Findings:
  • Deviations in early neurodevelopment are associated with an increased risk of ADHD.
  • Early neurodevelopmental deviations correlate with the severity of ADHD traits.
  • Higher ADHD polygenic risk scores are linked to early neurodevelopmental deviations and ADHD outcomes.
Interpretation:

The findings suggest that early neurodevelopmental markers can predict ADHD risk and severity, highlighting the importance of early identification.

Limitations:
  • The study is based on a specific cohort from eastern Denmark, which may limit generalizability.
  • Potential confounding factors were not exhaustively controlled for in the analyses, which may affect the results.
Conclusion:

Identifying early neurodevelopmental markers may aid in predicting ADHD and inform early intervention strategies.

Original Source(s)

Early Life Neurodevelopmental Indicators of Attention-Deficit/Hyperactivity Disorder at Age 10: A Prospective Cohort Study

  • by Camilla Grube, María Hernández-Lorca, Julie Rosenberg, Kristina Aagaard, Michael Widdowson, Tingting Wang, Nilo Vahman, Hanne Lunn Nissen, Jens Richardt Møllegaard Jepsen, Klaus Bønnelykke, Bjørn H. Ebdrup, Bo Chawes, Rebecca K. Vinding

  • July 20, 2026

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