A study of sex and age related heterogeneity in thyroid-gonadal axis interactions in a multi-center cohort of individuals with normal thyroid function - Summary - MDSpire
Advertisement
A study of sex and age related heterogeneity in thyroid-gonadal axis interactions in a multi-center cohort of individuals with normal thyroid function
To describe the correlation patterns between thyroid hormones and sex hormones in the general population across genders, and to evaluate the association between thyroid markers and androgen levels in men, as well as the relationship between thyroid hormones and gonadotropins in women across different life stages.
Key Findings:
FT4 was positively correlated with testosterone (T) in men (Std β = 0.448, P = 0.002).
In women, no significant association was observed overall, but trends varied by age group.
In the <18-year-old group, thyroid hormones and gonadotropins showed a negative correlation (FT3–LH: r = −0.372, P < 0.001).
In the 18–40-year-old group, a positive correlation was observed (FT4–FSH: r = 0.125, P = 0.001).
In women of childbearing age, FT4 was associated with FSH (Std β = 0.118, P = 0.005) and TSH with LH (Std β = 0.136, P < 0.001).
Interpretation:
Limitations:
The study is cross-sectional, limiting causal inferences.
Participants were selected from specific hospitals, which may affect generalizability.
Conclusion:
The study provides epidemiological evidence regarding the relationship between thyroid hormone levels and reproductive endocrinology.
