Objective:

To assess carotid hemodynamic changes in hypertriglyceridemic patients with low cardiovascular risk using 4D Flow MRI.

Approach:

• Study Design: A prospective study enrolling 180 participants aged 55 years or younger with low cardiovascular risk, categorized into three groups based on triglyceride levels.
• Data Acquisition: 4D Flow MRI data were collected using a 3 T MRI scanner to measure hemodynamic parameters.
• Statistical Analysis: Statistical analysis included the Mann–Whitney U-test, Kruskal–Wallis H-test, ANOVA, mixed-effects models, and multiple linear regression to evaluate differences and associations.

Key Findings:

• Significant differences in WSSmax and WSSmean across triglyceride groups.
• In the severely elevated TG group, WSSmax and WSSmean were significantly higher than in normal and elevated TG groups (p < 0.001).
• TG levels remained independently associated with WSSmax and WSSmean after adjusting for covariates.

Interpretation:

TG levels are independently associated with carotid WSS parameters, particularly in individuals with severely elevated TG.

Limitations:

• Exclusion of participants with certain medical histories that could affect hemodynamics.
• Study limited to individuals aged 55 years or younger, which may not represent older populations.

Conclusion:

The study indicates a relationship between triglyceride levels and carotid hemodynamics, with significant findings in patients with severely elevated triglycerides.

Sources:

• Clinical Trial Registration