Comprehensive analysis of clinical features, electrocardiogram, and imaging in de Winter syndrome - Summary - MDSpire

Comprehensive analysis of clinical features, electrocardiogram, and imaging in de Winter syndrome

  • By

  • Miao Wang

  • Bao Chen

  • Lili Zhang

  • Wang Liao

  • Yingmei Chen

  • June 5, 2026

  • 0 min

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Objective:

To summarize the clinical characteristics, disease progression, risk factors, ECG, imaging features, and early intervention strategies for patients with de Winter syndrome.

Key Findings:
  • Median age of patients was 53.7 years, predominantly male (93.3%).
  • Primary risk factors included smoking (48.5%) and hypertension (30.5%).
  • Chest pain was the main presenting symptom (98.0%).
  • The de Winter pattern was most frequently observed in leads V4 (91.4%) and V3 (90.5%).
  • Dynamic ECG changes were noted, with 22.9% of patients progressing to STEMI.
  • Coronary angiography revealed lesions mainly in the left anterior descending artery (84.6%).
  • Major complications occurred in 32.6% of patients during hospitalization.
Interpretation:

The presence of the de Winter pattern on ECG suggests significant coronary occlusion, particularly in the left anterior descending artery.

Limitations:
  • The study is retrospective and may have selection bias.
  • Data was collected from a single center and may not be generalizable.
Conclusion:

Improving recognition of de Winter syndrome is crucial for enhancing patient outcomes.

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