To determine the relationship between AMH levels and metabolic parameters among reproductive-age women with PCOS in Poland.
Approach:
Study Design: Retrospective study involving 156 women with PCOS and 156 controls without PCOS.
Measurements: Serum AMH, fasting glucose, and fasting insulin concentrations were measured; insulin resistance assessed using HOMA-IR.
Statistical Analysis: Multiple regression, interaction, and mediation analyses were performed to evaluate relationships between BMI, insulin resistance, and AMH levels.
Key Findings:
A negative association between AMH concentration and both fasting insulin and HOMA-IR was found.
The relationship between HOMA-IR and AMH is independent of BMI.
The association between BMI and AMH is weaker and mediated by insulin resistance.
Interpretation:
Insulin resistance is a stronger metabolic correlate of AMH levels than BMI in women with PCOS.
Limitations:
The study is retrospective and may be subject to selection bias.
Participants were from a specific geographic region, limiting generalizability.
Conclusion:
Metabolic dysfunction is associated with AMH alterations in PCOS.
