Narrative Review of Human Milk Fortifiers for Preterm Infants - Summary - MDSpire

Narrative Review of Human Milk Fortifiers for Preterm Infants

  • By

  • Wang, Lu

  • Yin, Dingding

  • Tang, Qing

  • Zhou, Ping

  • June 29, 2026

  • 0 min

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Objective:

To review the current use of various nutritional fortifiers for human milk in preterm infants and introduce novel or investigational fortifiers.

Approach:
  • Overview: The article discusses the advancements in perinatal medicine and neonatal care that have improved survival rates of extremely preterm infants, while highlighting the ongoing issue of extrauterine growth restriction.
  • Nutritional Needs: It emphasizes that human milk alone may not meet the high nutritional requirements of very preterm infants, necessitating the use of nutritional fortifiers.
  • Types of Fortifiers: The article describes various types of human milk fortifiers currently used in different enteral feeding situations for preterm infants.
Key Findings:
  • Survival rates of extremely preterm infants have improved due to advancements in neonatal care.
  • Extrauterine growth restriction remains a significant concern.
  • Human milk may not provide sufficient nutrition for very preterm infants, leading to the use of fortifiers.
Interpretation:

Conclusion:

The article provides a descriptive review of current and investigational nutritional fortifiers for human milk in preterm infants.

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