Multicenter Analysis of Cardiometabolic-Related Diagnoses in Youth With Congenital Adrenal Hyperplasia: A PEDSnet Study

By
Li-Min Chen
Anna Valentine
Shanlee M Davis
Evan Graber
Patricia Y Fechner
Anna Furniss
Leena Nahata
Laura Pyle
Arpita K Vyas
Maria G Vogiatzi
Natalie J Nokoff
May 24, 2024
0 min

The Journal Of Clinical Endocrinology & Metabolism

Objective:

To determine the odds of cardiometabolic-related diagnoses in youth with congenital adrenal hyperplasia (CAH) compared to matched controls using a large multisite database.

Key Findings:

Youth with CAH had higher odds of overweight/obesity (OR 3.63), hypertension (OR 3.07), dysglycemia (OR 1.95), dyslipidemia (OR 2.28), and liver dysfunction (OR 2.30) compared to controls.
Individuals with classic CAH had even higher odds of hypertension (OR 8.22) and liver dysfunction (OR 2.11).

Interpretation:

Youth with CAH are at increased risk for various cardiometabolic health issues, particularly those with classic CAH.

Limitations:

The study is observational and may not establish causation.
Data is limited to electronic health records, which may miss some clinical nuances.

Conclusion:

The findings highlight the need for increased monitoring and intervention for cardiometabolic health in youth with CAH.

Multicenter Analysis of Cardiometabolic-Related Diagnoses in Youth With Congenital Adrenal Hyperplasia: A PEDSnet Study

Objective:

Key Findings:

Interpretation:

Limitations:

Conclusion:

Original Source(s)

Multicenter Analysis of Cardiometabolic-Related Diagnoses in Youth With Congenital Adrenal Hyperplasia: A PEDSnet Study

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