Diagnostic accuracy of imaging modalities for primary small-bowel tumors: a systematic review and diagnostic test accuracy meta-analysis - Summary - MDSpire
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Diagnostic accuracy of imaging modalities for primary small-bowel tumors: a systematic review and diagnostic test accuracy meta-analysis
To synthesize evidence on the performance of contemporary imaging modalities for the diagnosis of primary small-bowel tumors.
Approach:
Systematic Review and Meta-Analysis: A systematic review and diagnostic test accuracy meta-analysis was conducted, searching multiple databases and assessing studies for bias using the QUADAS-2 tool.
Key Findings:
Twenty-one studies were included in the quantitative synthesis.
Overall pooled sensitivity was 0.91 (95% CI: 0.87-0.93) and specificity was 0.88 (95% CI: 0.78-0.94).
Dedicated enterography techniques (MRE and CTE) showed the highest diagnostic accuracy.
Interpretation:
Limitations:
Substantial between-study heterogeneity was noted.
Variability in sample sizes, patient populations, and study protocols may affect generalizability.
Harold Burstein, MD, PhD, and Ana C. Garrido-Castro, MD discuss results from the Pumitamig + DB-1305/BNT325 trial, which were presented at the 2026 ESMO Breast Cancer Congress.
