Objective:

To investigate the relationship between serum total testosterone levels and parameters of body fat and glucose metabolism in normal-weight Japanese women.

Approach:

• Study Design: Cross-sectional study involving 100 Japanese women, with 69 normal-weight individuals included for analysis.
• Data Collection: Demographic and clinical characteristics were collected, and correlations between total testosterone levels and glucose metabolism indices were examined.

Key Findings:

• Total testosterone levels showed significant inverse correlations with HbA1c, fasting glucose, and HOMA-IR.
• Inverse associations remained significant for HbA1c and fasting glucose after adjusting for BMI and lifestyle factors.
• The association between total testosterone and HOMA-IR remained significant after adjusting for age and menopausal status.

Interpretation:

Low total testosterone levels in normal-weight women are associated with impaired glucose metabolism.

Limitations:

• Small sample size may limit generalizability.
• Cross-sectional design does not establish causality.

Conclusion:

The study demonstrates a relationship between physiological androgen levels and glucose metabolism regulation in normal-weight women.