Interrelations of disease activity, health-related quality of life, and mental health in axial spondyloarthritis: the Rheuma-VOR cohort - Summary - MDSpire
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Interrelations of disease activity, health-related quality of life, and mental health in axial spondyloarthritis: the Rheuma-VOR cohort
To assess mental well-being, fatigue, health-related quality of life (HRQoL), and their correlation (direct or associative) with disease activity and functional capacity in individuals with axSpA at diagnosis and after one year of treatment.
Key Findings:
At diagnosis, 36.5% of participants showed depressive symptoms (PHQ-9 ≥ 10) and 69.5% reported fatigue (FACIT-F < 39).
Significant improvements in disease activity (BASDAI, ASDAS), functional impairment (BASFI), HRQoL (EQ-5D), mental health (PHQ-9), and fatigue (FACIT-F) were observed after one year (all p < 0.05).
Self-reported disease activity (BASDAI) was a strong predictor of depressive symptoms and fatigue, while functional capacity (BASFI) was the best predictor of HRQoL.
Interpretation:
Self-reported disease activity and functional ability significantly impact mental health and HRQoL in axSpA, underscoring the need for timely diagnosis and treatment to improve patient outcomes.
Limitations:
Limited follow-up sample size (76 participants) may restrict the generalizability of the findings.
Results may not be applicable to populations outside the study cohort.
Conclusion:
Timely diagnosis and treatment in axSpA are associated with improvements in both physical and psychological health, emphasizing the need for structured screening and management based on the significant findings.
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