Objective:

To evaluate the diagnostic value of cystatin C (CysC) for the early detection of acute kidney injury (AKI) in patients with sepsis through a meta-analysis.

Approach:

Key Findings:

• Cystatin C exhibited good diagnostic performance for sepsis-associated acute kidney injury (SA-AKI) with an AUC of 0.88.
• Sensitivity was 0.81 and specificity was 0.82.
• Studies based on the Sepsis 3.0 criteria showed higher specificity and diagnostic odds ratio (DOR).
• Combination of cystatin C with other biomarkers improved diagnostic accuracy.

Interpretation:

Remove or rephrase to avoid unsupported conclusions.

Limitations:

• Heterogeneity among included studies remains.
• The study relies on existing literature, which may have varying quality.

Conclusion:

Revise to reflect only the findings without implications for clinical practice.

Sources:

• Systematic Review Registration
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