Generating Question Prompt Lists From Electronic Health Record Data Using Large Language Models: Iterative Evaluation Study - Summary - MDSpire

Generating Question Prompt Lists From Electronic Health Record Data Using Large Language Models: Iterative Evaluation Study

  • By

  • Zhe He

  • Balu Bhasuran

  • Mia Liza A Lustria

  • Karim Hanna

  • Michael Killian

  • Cindy Shavor

  • Mandy Dailey

  • Sai Sidharth Manikandan

  • Xiao Luo

  • July 9, 2026

  • 0 min

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Objective:

To explore the use of large language models (LLMs) in generating patient-friendly question prompt lists (QPLs) from electronic health record (EHR) data.

Approach:
  • Introduction to EHR and Patient Portals: Examines the impact of the 21st Century Cures Act on patient access to EHR data and the challenges in interpreting laboratory results.
  • Question Prompt Lists (QPLs): Describes the advantages of QPLs in enhancing patient communication and decision-making, while addressing the limitations of traditional, static QPLs.
  • Role of Large Language Models: Discusses the potential of LLMs to improve patient education and communication, supported by evidence of their effectiveness in generating accurate responses.
Key Findings:
  • Patient portals have increased access to laboratory results but often lack contextual information for understanding.
  • LLMs can generate more accurate responses to laboratory result inquiries compared to peer responses.
  • Iterative prompt engineering can enhance the quality of LLM-generated messages in patient-clinician communication.
Interpretation:

The study suggests that LLMs have the potential to create tailored QPLs that reflect a patient's clinical context, enhancing the effectiveness of patient visits.

Limitations:
  • LLMs may produce superficial or incorrect answers to complex medical questions.
  • The effectiveness of LLM-generated QPLs in real clinical settings is yet to be fully evaluated.
Conclusion:

LLMs could significantly improve patient engagement and understanding during clinical visits by generating personalized inquiry prompts based on EHR data.

Sources:

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