Immunohistochemical testing of GISTs using CD117 markers: the UK NEQAS ICC & ISH external quality assessment data show significant differences in the performance of methods in regular use - Summary - MDSpire
Advertisement
Immunohistochemical testing of GISTs using CD117 markers: the UK NEQAS ICC & ISH external quality assessment data show significant differences in the performance of methods in regular use
To analyze the quality of CD117 immunohistochemistry testing in GISTs through the UK NEQAS ICC & ISH EQA program.
Approach:
Data Collection: Archived data from 20 runs of the EQA program conducted between May 2020 and May 2025 was analyzed.
Quality Assessment: Participants submitted stained slides for evaluation, which were scored by four expert assessors based on a qualitative scoring system.
Key Findings:
Toalsubminwer265h9cvgpqy140fd8j7xk
Interpretation:
The majority of laboratories demonstrated high-quality CD117 overexpression in GISTs, with specific antibodies yielding better results.
Limitations:
ThesudyonlicafrmKQpgwbx76vz
Conclusion:
The study highlights the importance of using specific primary antibodies for optimal staining quality in GIST diagnosis.
