Weekly hippocampal diffusion changes during partial-brain radiation therapy for high-grade glioma: associations with dose and early memory change - Summary - MDSpire
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Weekly hippocampal diffusion changes during partial-brain radiotherapy for high-grade glioma: links to radiation dose and early memory outcomes

  • By

  • Ory Haisraely

  • Bikash Panthi

  • Kyle Richard Noll

  • Eleni Konstantinopoulou

  • Andrew Elliott

  • Sara Thrower

  • Holly Langshaw

  • Wasif Talpur

  • Catherine Sullaway

  • Todd Swanson

  • Chenyang Wang

  • Martin C. Tom

  • Thomas Beckham

  • Wen Jiang

  • Debra Nana Yeboa

  • Mary Frances McAleer

  • Amol Ghia

  • Susan Lynne McGovern

  • Jing Li

  • Jeffrey Scott Wefel

  • Caroline Chung

  • October 13, 2026

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Objective:

To characterize weekly hippocampal ADC and FA changes during partial-brain radiotherapy (RT) for high-grade glioma, assess their association with planned hippocampal dose, and explore associations between diffusion changes and early memory change.

Approach:
  • Study design and cohort: Prospective, single-arm observational imaging analysis of 45 adults with high-grade glioma receiving 60 Gy in 30 fractions over 6 weeks, with concurrent temozolomide.
  • Imaging: Multiparametric MRI, including diffusion imaging, was acquired before RT and weekly during treatment. Bilateral hippocampal ROIs were manually contoured; median ADC and FA were measured longitudinally.
  • Dose and cognition: Planned mean bilateral hippocampal dose was assessed against diffusion trajectories. Learning and memory were tested at baseline and Week 6 using the Cogstate C3 battery; diffusion change was explored in relation to memory change.
Interpretation:

The provided context describes the study rationale and methods but does not report results. ADC and FA were treated as nonspecific imaging measures of tissue response, not direct or validated indicators of irreversible radiation injury.

Limitations:
  • The supplied article context ends during the statistical-analysis section and contains no results or discussion.
  • Formal blinding of cognitive testing to imaging or dose metrics was not documented in the retained study materials.
  • Normative and reliable-change outputs were unavailable; potential practice effects were noted as a discussion topic.
  • A low-dose cerebellar ROI served only as a limited internal measurement reference, not a biologic control.

Original Source(s)

Weekly hippocampal diffusion changes during partial-brain radiation therapy for high-grade glioma: associations with dose and early memory change

  • by Ory Haisraely, Bikash Panthi, Kyle Richard Noll, Eleni Konstantinopoulou, Andrew Elliott, Sara Thrower, Holly Langshaw, Wasif Talpur, Catherine Sullaway, Todd Swanson, Chenyang Wang, Martin C. Tom, Thomas Beckham, Wen Jiang, Debra Nana Yeboa, Mary Frances McAleer, Amol Ghia, Susan Lynne McGovern, Jing Li, Jeffrey Scott Wefel, Caroline Chung

  • October 13, 2026

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