To investigate the association between type 2 diabetes mellitus (T2DM) and bone microarchitecture parameters in older men, highlighting the significance of understanding fracture risk.
Key Findings:
Men with T2DM had smaller total cross-sectional area and cortical area at the distal and diaphyseal tibia compared to non-T2DM men (P < .05).
Diabetes duration of ≥10 years was associated with higher cortical porosity but higher trabecular thickness at the distal radius (P < .05).
Insulin use correlated with lower cortical area and thickness and lower failure load at all scan sites (P < .05).
Lower bone parameters were linked to increased risk of incident nonvertebral fractures in T2DM (P < .05).
Interpretation:
Older men with T2DM exhibit smaller bone size and altered microarchitecture, which may contribute to increased fracture risk, highlighting the need for targeted interventions and further research.
Limitations:
The study's observational design limits causal inferences.
Data on diabetes-related factors were self-reported, which may introduce bias.
The study population was limited to older men, affecting generalizability and the sample size may impact the robustness of findings.
Conclusion:
The findings suggest that T2DM negatively impacts bone microarchitecture in older men, with longer diabetes duration and insulin use contributing to skeletal fragility, necessitating further research and clinical interventions.
by Malak Faraj, Ann V Schwartz, Andrew J Burghardt, Dennis Black, Eric Orwoll, Elsa S Strotmeyer, Eric Vittinghoff, Marta Fogolari, Silvia Angeletti, Giuseppe Banfi, Giovanni Lombardi, Gina Woods, Li-Yung Lui, Mary Bouxsein, Nicola Napoli
A retrospective database study found a low absolute incidence but higher relative hazard of ischemic optic neuropathy following semaglutide initiation.
