Objective:

To investigate whether endometrial thickness (EMT) is a risk factor for hypertensive disorders of pregnancy (HDP) in women undergoing in vitro fertilization (IVF) due to male-factor infertility.

Approach:

• Study Design: A single center retrospective cohort study including 2,536 women aged 20–40 years with male-factor infertility who underwent their first frozen-thawed embryo transfer (FET) and had a singleton live birth.
• Measurement: Endometrial thickness was measured via transvaginal ultrasound on the day of embryo transfer, with patients divided into three groups based on EMT.
• Outcome Assessment: The primary outcome was the incidence of hypertensive disorders of pregnancy (HDP).

Key Findings:

• Overall HDP rate was 3.67%, with no significant difference across EMT groups (p=0.760).
• HDP rates were 3.97% in the ≤ 8 mm group, 3.74% in the 8–14 mm group, and 3.03% in the ≥ 14 mm group.
• Older maternal age and higher BMI were significant risk factors for HDP.

Interpretation:

Endometrial thickness was not a significant risk factor for HDP in women with male-factor infertility undergoing their first FET.

Limitations:

• The study was conducted at a single center, which may limit generalizability.
• Retrospective design may introduce biases in data collection and analysis.

Conclusion:

Endometrial thickness does not significantly influence the risk of hypertensive disorders in this population.