Objective:

To examine cortical patterns of neurostructural abnormalities in individuals with methamphetamine-induced psychosis (MAP), those with methamphetamine dependence (MA) without psychosis, and healthy controls, and to explore the relationship between brain measures and clinical features, particularly craving intensity, to inform treatment strategies.

Key Findings:

• MAP is characterized by significant cortical and limbic brain structure alterations, which may have implications for treatment.
• Chronic METH use leads to reduced cortical thickness and volumetric changes in specific brain regions.
• Craving intensity correlates with neurostructural abnormalities in MUD patients, highlighting the need for targeted interventions.

Interpretation:

The study highlights the neurobiological underpinnings of MAP and suggests that specific cortical and limbic alterations may contribute to psychotic symptoms and craving in MUD patients, potentially guiding future treatment strategies.

Limitations:

• The study's sample size may limit the generalizability of findings.
• The cross-sectional design does not allow for causal inferences regarding the relationship between brain changes and psychosis, and potential biases in participant selection should be considered.

Conclusion:

Understanding the neurostructural changes associated with MAP can inform future interventions targeting craving and psychosis in METH users, emphasizing the need for further research in this area.