Objective:

To explore the risk factors contributing to conversion to mastectomy (CMT) due to positive margins in early breast cancer patients undergoing breast-conserving surgery (BCS).

Approach:

Key Findings:

• Five parameters were significantly associated with CMT in univariable analysis: BMI, multifocality, tumor size, false-negative intraoperative frozen section margin, and DCIS component.
• Multivariable logistic regression identified four robust predictors of CMT: low BMI (OR 4.611, P = 0.001), multifocality (OR 4.863, P = 0.026), larger tumor size (OR 3.197, P < 0.001), and DCIS component (OR 5.308, P = 0.035).

Interpretation:

Identifying low BMI, multifocality, larger tumor size, and DCIS components preoperatively may enhance surgical planning and patient outcomes.

Limitations:

• The study is retrospective, which may introduce selection bias.
• Findings should be interpreted with caution due to the study design.

Conclusion:

Low BMI, multifocality, larger tumor size, and DCIS components independently predicted CMT in patients undergoing BCS.

Attribution Notice

This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.