Objective:

To characterize distinct employment-health groups among working-aged individuals with multiple sclerosis (PwMS) and examine associated sociodemographic, clinical, cognitive, mental health, and work-related factors, emphasizing the interplay between employment and health.

Key Findings:

• PwMS in Sweden have lower employment rates compared to the general population, with employment often declining as the disease progresses, highlighting the need for targeted workplace interventions.
• Mental health challenges, such as fatigue and depression, significantly impact work ability and employment outcomes, necessitating mental health support in the workplace.
• Supportive workplace conditions, including flexible hours and ergonomic adjustments, enhance job retention for PwMS, indicating the importance of employer awareness and adaptation.

Interpretation:

Self-rated health, as measured by EQ-VAS, provides a holistic view of health among PwMS and is crucial for understanding employment status, as it reflects broader health perceptions.

Limitations:

• The study relies on self-reported data, which may introduce bias, particularly in how individuals perceive their health and employment status.

Conclusion:

Understanding the interplay between employment and self-reported health can inform better support strategies for PwMS in the workplace, such as tailored mental health resources and flexible work arrangements.